These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Axonal loss of white matter in migraine without aura: a tract-based spatial statistics study.
    Author: Yu D, Yuan K, Qin W, Zhao L, Dong M, Liu P, Yang X, Liu J, Sun J, Zhou G, von Deneen KM, Tian J.
    Journal: Cephalalgia; 2013 Jan; 33(1):34-42. PubMed ID: 23150889.
    Abstract:
    AIM: Multiple diffusion tensor imaging (DTI) derived indices may help to deduce the pathophysiological type of white matter (WM) changes and provide more specific biomarkers of WM neuropathology in the whole brain of migraine patients without aura (MWoA). METHODS: Twenty MWoA and 20 age-, education- and gender-matched healthy volunteers participated in this study. Tract-based spatial statistics (TBSS) was employed to investigate the WM abnormalities in MWoA by integrating multiple indices, including fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD). RESULTS: Compared with healthy controls, MWoA showed significantly lower FA, MD and AD in multiple brain regions, whereas no difference in RD was observed. Specifically, the overlap among the lower FA, MD, and AD was found in the genu, body, and splenium part of the corpus callosum (CC), the right anterior limb of the internal capsule (ALIC) and the posterior limb of the internal capsule (PLIC) in MWoA compared with healthy controls. Additionally, some of the above WM findings were significantly correlated with duration and headache frequency in MWoA. CONCLUSION: Given that decreased AD may suggest axonal loss, our findings may reveal axonal loss in MWoA.
    [Abstract] [Full Text] [Related] [New Search]