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  • Title: Postnatal activity of angiotensin converting enzyme in rat brain.
    Author: Singh EA, McGeer EG.
    Journal: Dev Neurosci; 1979; 2(5):245-8. PubMed ID: 231511.
    Abstract:
    The specific activity of angiotensin converting enzyme (ACE) was studied in eight brain regions in rats 2--65 days of age. At 65 days of age the activities in various regions relative to the cortex were: neostriatum, 1,200%; hippocampus/amygdala, 430%; hypothalamus, 190%; cerebellum, 140%; and midbrain, thalamus and pons/medulla, 110%. Significant linear increases were found in the neostriatum, hippocampus/amygdala and cortex at 2--65 days of age, in the pons/medulla and thalamus at 2--42 days of age and in the midbrain at 2--21 days of age. The increase with age was greatest in the neostriatum and the data are consistent with the occurrence of ACE in neurons in this area.
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