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  • Title: Assembly of spirooxindole derivatives via organocatalytic iminium-enamine cascade reactions.
    Author: Albertshofer K, Anderson KE, Barbas CF.
    Journal: Org Lett; 2012 Dec 07; 14(23):5968-71. PubMed ID: 23151228.
    Abstract:
    The assembly of complex spirocyclopentaneoxindoles via a novel organocatalytic iminium-enamine cascade process is reported. Reactions between 3-substituted oxindoles and α,β-unsaturated aldehydes catalyzed by second generation prolinol ethers provided the desired products in high yield with excellent levels of enantioselectivity in a single step.
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