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  • Title: Facile water promoted synthesis of 1,2,3-triazolyl dihydropyrimidine-2-thione hybrids - highly potent antibacterial agents.
    Author: Sangaraiah N, Murugan S, Poovan S, Raja R, Alagusundaram P, Ramakrishnan V, Vellasamy S.
    Journal: Eur J Med Chem; 2012 Dec; 58():464-9. PubMed ID: 23151322.
    Abstract:
    An elegant and efficient synthesis of hitherto novel 1,2,3-triazolyl dihydropyrimidine-2-thione hybrids has been accomplished for the first time in a green solvent viz. water. The hybrid molecules exhibit significant antibacterial activity when screened against four human pathogens viz. Streptococcus pneumonia, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi. In comparison to the commercially marketed tetracycline, some of them were equally potent and a few more potent.
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