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  • Title: Gluconeogenic key enzymes in normal and intrauterine growth-retarded newborn rats.
    Author: Kollée LA, Monnens LA, Trijbels JM, Veerkamp JH, Janssen AJ, van Haard-Hustings H.
    Journal: Early Hum Dev; 1979 Dec; 3(4):345-52. PubMed ID: 231514.
    Abstract:
    Intrauterine growth retardation was induced in rats by ligation of the artery of one of both uterine horns. Activities of pyruvate carboxylase, phosphoenolpyruvate carboxykinase, fructose-1,6-diphosphatase and glucose-6-phosphatase in liver were measured at 0, 1, 3 and 6 h after delivery in newborn rats from normal and sham-operated litters, and from ligated and contralateral uterine horns. Lower activities of fructose-1,6-diphosphatase were found in small-for-gestational-age animals in comparison with animals from contralateral horns. When small-for-gestational-age animals were compared with animals from sham litters (which could be regarded as more satisfactory controls), the activities of two other gluconeogenic enzymes (pyruvate carboxylase and glucose-6-phosphatase) appeared to be lower as well. It is concluded that a delay in the development of these gluconeogenic enzymes could play a role in neonatal hypoglycemia in small-for-gestational-age rats.
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