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  • Title: Two-stage amplification of receptors using a multilevel orthogonal/simultaneous dynamic combinatorial library.
    Author: Escalante AM, Orrillo AG, Cabezudo I, Furlan RL.
    Journal: Org Lett; 2012 Dec 07; 14(23):5816-9. PubMed ID: 23153248.
    Abstract:
    Sequential activation of different reversible exchange reactions in a dynamic combinatorial library allows directed exploration of the chemical space: initially a macrocyclic scaffold is selected by the template and finally side chain and conformational constrains are introduced into such a scaffold.
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