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  • Title: Tyrosine loading increases dopamine metabolite concentrations in the brain.
    Author: Chance WT, Foley-Nelson T, Nelson JL, Fischer JE.
    Journal: Pharmacol Biochem Behav; 1990 Jan; 35(1):195-9. PubMed ID: 2315359.
    Abstract:
    Administration of haloperidol (1.5 mg/kg) to rats increased concentrations of dopamine metabolites in the corpus striatum, nucleus accumbens, hypothalamus and amygdala. Treatment of similar rats with various doses (25, 100 or 400 mg/kg) of tyrosine methyl ester in combination with the haloperidol led to additional elevations of 3,4-dihydroxyphenylacetic acid (DOPAC) in the corpus striatum and hypothalamus at the lowest dose tested. Therefore, it is concluded that during periods of increased neuronal activity, as induced by haloperidol, tyrosine availability may become a rate-limiting factor in dopamine metabolism.
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