These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthesis of novel indole hydrazone derivatives and evaluation of their antiplatelet aggregation activity.
    Author: Mashayekhi V, Haj Mohammad Ebrahim Tehrani K, Amidi S, Kobarfard F.
    Journal: Chem Pharm Bull (Tokyo); 2013; 61(2):144-50. PubMed ID: 23154304.
    Abstract:
    Based on the existing reports regarding the antiplatelet aggregation activity of hydrazone derivatives, a series of indole hydrazone derivatives were considered as potential antiplatelet agents and synthesized. The structures of the synthesized compounds were confirmed by spectral data and elemental analysis. The new indole hydrazone derivatives were evaluated for their ability to inhibit platelet aggregation induced by adenosine diphosphate (ADP) and arachidonic acid (AA). Compounds 1h and 3h exhibited remarkable activity against arachidonic acid induced platelet aggregation with IC(50) values comparable to that of indomethacin and compound 1i efficiently inhibited platelet aggregation induced by both ADP and AA.
    [Abstract] [Full Text] [Related] [New Search]