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  • Title: Surface markers and functional characteristics of human blood lymphocytes residing in the operational "null" subset.
    Author: Bakács T, Klein E, Steinitz M, Gergely P.
    Journal: Haematologia (Budap); ; 12(1-4):113-26. PubMed ID: 231548.
    Abstract:
    After removal of nylon wool-adherent B and E rosetting T cells from the human blood lymphocyte population, a small fraction remains, often denoted as "null" subset. This fraction contains lymphocytes which are highly efficient in antibody-dependent and non-selective lymphocyte cytotoxicity. These cells possess markers. About half of them carry Fc receptors, and the majority has low avidity E and C3 receptors. Removal of low avidity E receptor-carrying cells did not abolish cytotoxicity to K-562 cells. The majority of cells carry receptors for Epstein-Barr virus but cannot be infected. The cells in mixed lymphocyte culture have a low reactivity. They aare stimulated by PHA and ConA to a similar extent and differ from the cells which readily sediment as E rosettes: these respond stronger to PHA. The "null" fraction may contain stem cells common for both T and B lineages.
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