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  • Title: Measurement of pulmonary parenchymal attenuation: use of spirometric gating with quantitative CT.
    Author: Kalender WA, Rienmüller R, Seissler W, Behr J, Welke M, Fichte H.
    Journal: Radiology; 1990 Apr; 175(1):265-8. PubMed ID: 2315492.
    Abstract:
    A new approach to reproducible measurement of lung attenuation and structure by means of respiratory-gated computed tomography (CT) was developed. The patient breathes through a microcomputer-controlled pocket spirometer during the complete CT examination, starting with a measurement of the vital capacity. At a user-selected respiratory level, the CT scan is triggered and air flow is inhibited mechanically. To exclude operator-related reproducibility errors, evaluation is based on semiautomated algorithms that isolate lung parenchyma by fast contour tracing. In a study on one volunteer, measurement of lung attenuation changed by a factor of about 2.6 (-895 to -730 HU) as a function of inspirational status. Reproducibility on the order of 5% or better can be achieved only with tight spirometric control of respiration.
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