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  • Title: Association between family history of affective disorder and the depressive syndrome of Alzheimer's disease.
    Author: Pearlson GD, Ross CA, Lohr WD, Rovner BW, Chase GA, Folstein MF.
    Journal: Am J Psychiatry; 1990 Apr; 147(4):452-6. PubMed ID: 2316731.
    Abstract:
    For each of 41 index patients with probable Alzheimer's disease and a first episode of major depression and 71 nondepressed Alzheimer's disease patients, two first-degree relatives were interviewed by a rater blind to presence or absence of depression in the proband. The depressed patients had significantly more first- and second-degree relatives with depression than did control subjects. The lifetime risk for major depression, adjusted for differences in age distribution, was significantly greater in first-degree relatives of index patients, suggesting that depression in Alzheimer's disease is genetically related to primary affective disorder. Alzheimer's disease may be useful for studying aspects of depressive pathophysiology.
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