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  • Title: Dual positivity of hepatitis B surface antigen and anti-hepatitis C virus antibody and associated factors among apparently healthy patients of Ekiti State, Nigeria.
    Author: Oje OJ, Sule WF, Famurewa D.
    Journal: Viral Immunol; 2012 Dec; 25(6):448-55. PubMed ID: 23171358.
    Abstract:
    There are few studies on health-facility based prevalence rates for dual hepatitis B virus-hepatitis C virus (HBV-HCV) infection on a state-wide scale in Nigeria. In this study we determined the state-wide prevalence rate of dual positivity of hepatitis B surface antigen and anti-HCV antibody among hospital patients of Ekiti State, Nigeria, and identified associated factors. Consenting apparently-healthy patients visiting health centers in all local government area (LGA) headquarters of Ekiti State were consecutively selected to a total of 2000 individuals. Patient demographic data pertinent to HBV and HCV transmission were obtained using a structured questionnaire. Subsequently, serum samples prepared from the aseptically collected blood was tested for the presence of both HBsAg and anti-HCV antibody using DiaSpot test strips. The results were analyzed using binary logistic regression. Dual positivity of 7.40% was recorded among the study participants, with 9.80% and 12.80%, respectively, testing positive for HBsAg and anti-HCV antibody. The study patients were, however, most likely to be anti-HCV antibody positive. Nine of the 10 factors studied were independently associated with dual positivity. Five of these, in descending order of odds ratio, were: illiteracy (15.76, p=0.001); having ≥4 sexual partners (9.46, p=0.001); age range of 35-44 y (8.46,p=0.001); farming (7.33, p=0.001); and "not at all" to use of condoms during sexual intercourse (4.39, p=0.001). The dual positivity rate was relatively high, with unprotected sexual intercourse as the most probable mode of acquisition of HBV and HCV by the seropositive study participants.
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