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  • Title: Phenolic compounds and interaction between aminoglycosides and natural products of Lygodium venustum SW against multiresistant bacteria.
    Author: Morais-Braga MF, Souza TM, Santos KK, Guedes GM, Andrade JC, Tintino SR, Sobral-Souza CE, Costa JG, Saraiva AA, Coutinho HD.
    Journal: Chemotherapy; 2012; 58(5):337-40. PubMed ID: 23171666.
    Abstract:
    BACKGROUND: The aim of this work was to evaluate the interactions between aminoglycosides and the ethyl-acetate fraction of the fern Lygodium venustum SW (EAFLV) METHODS: The ethyl-acetate fraction was obtained from the ethanol extract of L. venustum and was assayed via the checkerboard method associated with aminoglycosides against two bacterial strains multiresistant to antibiotics. RESULTS: The antibiotic activity of all drugs, when associated with the ethyl-acetate fraction, was enhanced in an additive manner, except for the association between EAFLV and amikacin, which showed a synergistic interaction against the Escherichia coli strain. CONCLUSIONS: The results indicated that L. venustum can be a source of secondary metabolites to be used in association with antibiotics like aminoglycosides in antibiotic chemotherapy against resistant bacteria.
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