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  • Title: [Recombinant tumor necrosis factor promotes the formation of hematogenic metastases to the lungs of C57Bl/6 mice].
    Author: Kudriavets IuI, Didkovskaia LP.
    Journal: Eksp Onkol; 1990; 12(2):47-50. PubMed ID: 2318134.
    Abstract:
    The intravenous injection of the recombinant tumour necrosis factor (rTNF) to the C57BL/6 mice at a dose of 10(4) U 1.4 and 24 hours before or 4 hours after the intravenous inoculation of the LL (Lewis carcinoma) or MM-4 (B-16 melanoma) cells was found to be accompanied by a significant increase in the number of hematogenic metastases in the lungs of animals. The above rTNF effect could be considerably inhibited by the single heparin injection.
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