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  • Title: Thinned-skull cortical window technique for in vivo optical coherence tomography imaging.
    Author: Szu JI, Eberle MM, Reynolds CL, Hsu MS, Wang Y, Oh CM, Islam MS, Park BH, Binder DK.
    Journal: J Vis Exp; 2012 Nov 19; (69):e50053. PubMed ID: 23183913.
    Abstract:
    Optical coherence tomography (OCT) is a biomedical imaging technique with high spatial-temporal resolution. With its minimally invasive approach OCT has been used extensively in ophthalmology, dermatology, and gastroenterology. Using a thinned-skull cortical window (TSCW), we employ spectral-domain OCT (SD-OCT) modality as a tool to image the cortex in vivo. Commonly, an opened-skull has been used for neuro-imaging as it provides more versatility, however, a TSCW approach is less invasive and is an effective mean for long term imaging in neuropathology studies. Here, we present a method of creating a TSCW in a mouse model for in vivo OCT imaging of the cerebral cortex.
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