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  • Title: [Diagnosis of prospective malignancy of cervix dysplasia using DNA cytometry].
    Author: Bollmann R.
    Journal: Geburtshilfe Frauenheilkd; 1990 Feb; 50(2):113-7. PubMed ID: 2318402.
    Abstract:
    134 borderline lesions of the cervix uteri (CIN I/II) were investigated by using the newly developed diagnostic method DNA-image cytometry (MIAMED-DNA, Wild-Leitz, Wetzlar). The demonstration of aneuploid cells served as a marker for prospective malignancy. 18 out of 35 cases, which proved to be CIN III in the follow-up, had a malignant DNA diagnosis. The sensitivity of the diagnostic DNA cytometry for prospective malignancy was therefore 51.4%. All 43 cases with a negative DNA diagnosis proved to be negative in the follow-up, so that the specificity of DNA cytometry was 100%. Suspicious DNA diagnosis in 26% of the cases proved to be CIN III in the follow-up. DNA cytometry seems to be a reliable method to predict the biological behaviour of borderline lesions of the cervix uteri in everyday practice.
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