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  • Title: Laser interstitial thermotherapy of small breast fibroadenomas: numerical simulations.
    Author: Marqa MF, Mordon S, Betrouni N.
    Journal: Lasers Surg Med; 2012 Dec; 44(10):832-9. PubMed ID: 23184405.
    Abstract:
    BACKGROUND: Laser interstitial thermotherapy (LITT) is potentially a novel method to treat small breast fibroadenoma, without the need for surgical removal. Dosimetry planning and conformation of the treated area of tumor remain major issues, especially for a moving organ such as the breast. Pre-treatment simulation planning of this therapy is an effective method to predict the final thermal damage. In this study, a mathematical model is elaborated to simulate the heat distribution and the thermal damage. METHODS: The mathematical model was based on finite element method (FEM) to solve the light distribution, bioheat, and thermal damage equations. Six simulations were performed with the following powers: 5, 6, 7, 8, 9, and 10 W (λ = 980 nm), and for an irradiation time of 125 seconds, with a 50 °C iso-damage temperature. To validate these simulations, six turkey breast samples were irradiated with parameters used for simulations. Volumes of thermal damage were calculated by using formulas: spherical, Elliptical, and Carlsson volumes and compared to the simulated volumes. RESULTS: Differences between volumes were from 0.01 to 1 cm3. Interpolations between volumes from ex vivo experiments with corresponding powers were established. The relationship between the volume of the thermal damage and the laser power was described by a polynomial equation (R2  = 0.99). The power estimated by the interpolation to obtain 1 cm3 of thermal damage was 7.4 W (922 J) and the maximum corresponding temperature was 90 °C. CONCLUSION: In this study, a good correlation was established between simulation and ex vivo experiments of LITT for fibroadenoma breast cancer.
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