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  • Title: Enhanced enzymatic thermal stability and activity in functionalized mesoporous silica monitored by (31) p NMR.
    Author: El-Boubbou K, Schofield DA, Landry CC.
    Journal: Adv Healthc Mater; 2012 Mar; 1(2):183-8. PubMed ID: 23184722.
    Abstract:
    Organophosphorus hydrolase (OPH) is immobilized on ammonium-modified mesoporous silica particles. Thermal stability and activity are measured with a (31) P NMR assay of the conversion of paraoxon (toxic) to its non-toxic hydrolysis product. After immobilization, OPH is significantly more active at room temperature and retained activity even after being heated to 45 °C for 1 month.
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