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  • Title: Synthesis of the tetracyclic core of berkelic acid using gold(I)-catalyzed hydroarylation and oxidative radical cyclizations.
    Author: Brimble MA, Haym I, Sperry J, Furkert DP.
    Journal: Org Lett; 2012 Dec 07; 14(23):5820-3. PubMed ID: 23186011.
    Abstract:
    A synthetic approach to the tetracyclic core of berkelic acid is reported using gold(I)-catalyzed intramolecular hydroarylation and oxidative radical cyclizations to effect the key ring-forming steps. The carboxylic acid was introduced via a late-stage palladium-catalyzed carbonylation to afford the core tetracycle with the correct relative stereochemistry for the natural product.
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