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  • Title: Impact of immunosenescence on transplant outcome.
    Author: Heinbokel T, Hock K, Liu G, Edtinger K, Elkhal A, Tullius SG.
    Journal: Transpl Int; 2013 Mar; 26(3):242-53. PubMed ID: 23190423.
    Abstract:
    Aging affects all compartments of the immune response and has a major impact on transplant outcome and organ quality. Although clinical trials in the aging transplant population remain rare, our current understanding of immunosenescence provides a basis for an age-adapted immunosuppression and organ allocation with the goal to optimize utilization and to improve outcomes in older recipients. From a more general perspective, understanding the mechanisms and consequences of immunosenescence will have a broad impact on immune therapies in and beyond transplantation.
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