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  • Title: Podocarpane, isopimarane, and abietane diterpenoids from Isodon lophanthoides var. graciliflorus.
    Author: Liang Y, Xie H, Wu P, Jiang Y, Wei X.
    Journal: Food Chem; 2013 Feb 15; 136(3-4):1177-82. PubMed ID: 23194512.
    Abstract:
    Four new diterpenoids including two podocarpanes, graciliflorins A (1) and B (2), an isopimarane acetal, graciliflorin C (3), and a rearranged abietane, graciliflorin D (4) were isolated from the aerial parts of Isodon lophanthoides var. graciliflorus (Lamiaceae) along with podocarpa-8,11,13-triene-3α,13-diol (5) and micranthin B (6). Their structures were elucidated based on the spectroscopic data. The in vitro cytotoxicity of compounds 1-4 and 6 against human carcinoma A549, MCF-7, and HeLa cell lines were evaluated using the MTT colourimetric assay. Micranthin B (6) showed moderate activity against all the cells with IC(50) values of 16.29, 18.20, and 22.25 μM, while compounds 1-4 were inactive (IC(50)>50 μg/ml).
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