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  • Title: Superior vena cava syndrome caused by systemic lupus erythematosus in a patient with longstanding rheumatoid arthritis.
    Author: van den Brink H, Vroom TM, van de Laar MA, van Soesbergen RM, van der Korst JK.
    Journal: J Rheumatol; 1990 Feb; 17(2):240-3. PubMed ID: 2319523.
    Abstract:
    Superior vena cava syndrome is mostly related to a malignant process, but many different benign causes have also been described. We report a patient with longstanding classic rheumatoid arthritis (RA), who developed a superior vena cava syndrome due to mediastinal lymphadenopathy. At that time she also fulfilled the ARA criteria for systemic lupus erythematosus (SLE). Histological examination of a lymph node biopsy revealed necrosis, hematoxylin bodies and LE cells, while a great amount of amorphous proteinaceous material was seen positive with immunofluorescence for IgG, IgM and complement (C3 and Clq). A diagnosis of superior vena cava syndrome due to mediastinal lymphadenopathy in a patient with SLE which had evolved from longstanding RA was established.
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