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  • Title: [Emergence of linezolid-resistant Enterococcus faecalis strains from two inpatients in a pediatric ward].
    Author: Nihonyanagi S, Adachi Y, Onuki T, Nakazaki N, Hirata Y, Fujiki K, Takayama Y, Kanoh Y, Bandoh Y, Dantsuji Y, Hanaki H, Sunakawa K.
    Journal: Kansenshogaku Zasshi; 2012 Sep; 86(5):555-62. PubMed ID: 23198574.
    Abstract:
    We report herein on the isolation of three linezolid-resistant Enterococcus faecalis strains in 2011 from two pediatric inpatients at Kitasato University Hospital, Japan. Three linezolid resistant strains were isolated from two patients who shared the same room of a pediatric inpatient ward. Two linezolid resistant strains were isolated from patient A who had been treated with a total of 17,600mg of linezolid during 60 days of hospitalization (strains 1 and 2). The linezolid resistant E. faecalis persisted through the time that the patient had been discharged from the hospital. Another linezolid resistant strain was isolated from patient B who had no history of linezolid administration. The resistant strain in patient B phased out spontaneously. The minimum inhibitory concentration of linezolid in these strains ranged from 8.0 to 16.0 microg/mL. PCR amplification of the chromosomal gene encoding domain V of the 23S rRNA and subsequent nucleotide sequencing revealed that all the strains had at least one G2576T mutation. The pulse-field-gel electrophoretograms of the DNA treated with the SmaI restriction enzyme showed an identical profile suggesting that they were derived from a single resistant strain. These results suggested that the resistant strain occurred in patient A and was transmitted to patient B within the inpatient ward.
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