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  • Title: [Cerebral perfusion pressure in acute blood pressure decrease with hyperosmolar sorbitol in anesthesia conditions].
    Author: Panning B, Stolke D.
    Journal: Neurochirurgia (Stuttg); 1990 Mar; 33(2):37-41. PubMed ID: 2320197.
    Abstract:
    Osmotherapy with sorbitol during intracranial surgery caused a significant decrease in arterial blood pressure. It was shown that this sometimes very desirable reaction did not cause relevant decreases in cerebral perfusion pressure, but was on the contrary accompanied by an increase in cerebral perfusion pressure in patients with severely elevated ICP (greater than 30 mmHg). 8 patients were studied by measuring the arterial and intracranial pressure during intraoperative infusions of sorbitol 40% (3 ml/kg body weight). Our findings are explained by the simultaneous decrease in arterial and intracranial pressure. During intracranial surgery sorbitol can be used as the antihypertensive agent of choice for treating hypertensive dysregulation of arterial blood pressure in the initial phase of craniotomy before opening the dura.
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