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  • Title: Cranial nerve dysfunction in conscious galactosemic rats as measured by the auditory-evoked brainstem response.
    Author: Notvest RR, Inserra JJ, Emrey TA, Sredy J.
    Journal: Proc Soc Exp Biol Med; 1990 Apr; 193(4):264-8. PubMed ID: 2320597.
    Abstract:
    The purpose of this study was to extend our previous work with the auditory-evoked brainstem response and determine whether galactosemia would produce a functional neuropathy similar to that previously seen in streptozocin-induced diabetic rats. Sprague-Dawley male rats implanted with cortical electrodes received either normal chow (n = 17) or a 50% galactose diet (n = 17) for 5 weeks. Peak II latency of the auditory-evoked brainstem response, interpreted as a functional measure of the auditory nerve (VIII cranial) in rats, was significantly prolonged in galactose-fed rats relative to controls (P less than 0.05). These results demonstrate a functional deficit in the auditory nerves of galactosemic rats. The deficit in the auditory-evoked brainstem response of galactosemic rats is similar to our previous finding in streptozocin-induced diabetic rats.
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