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  • Title: RGO LBL modified biomimetic electrochemical sensor for detection of Sildenafil in herbal sexual health products.
    Author: Li Y, Wen T, Xue C, Han Q, Wang Y, Hong J, Zhou X, Jiang H.
    Journal: Biosens Bioelectron; 2013 Apr 15; 42():287-92. PubMed ID: 23208100.
    Abstract:
    In this work, a highly sensitive and selective biomimetic electrochemical sensor for Sildenafil in herbal sexual health products was prepared. Reduced graphene oxide (RGO), a novel highly conductive material was used to modify glassy carbon electrode (GCE) through layer-by-layer (LBL) self-assembly. The conductive molecularly imprinted films were constructed on the functional electrode surface using Sildenafil as template molecules, p-phenylenediamine (p-PD) as functional monomers. The obtained molecularly imprinted electrochemical sensor (MIES) was successfully used to detect Sildenafil in herbal sexual health products. The limit of detection (LOD) was 6.2 nmol L⁻¹. The recoveries for the spiked Sildenafil contents were in the range of 92.34-97.71% with the RSD < 2.31%. The selective efficiencies for Sildenafil and other structurally related analogues only slightly varied from 0.93 to 1.09.
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