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  • Title: Electrochemical determination of purine and pyrimidine DNA bases based on the recognition properties of azocalix[4]arene.
    Author: Qin X, Liu X, Hong-Bo L, Li-Na Y, Xiaoya H.
    Journal: Biosens Bioelectron; 2013 Apr 15; 42():355-61. PubMed ID: 23208110.
    Abstract:
    The azocalix[4]arene film modified glassy carbon electrode was established for the convenient and sensitive detection of four DNA bases (guanine, adenine, thymine and cytosine). Field emission scanning electron microscopy, attenuated total reflectance-FTIR and X-ray photoelectron spectroscopy were used to characterize the film. The azocalix[4]arene film exhibited excellent electrocatalytic activity toward the oxidation of all bases. Well-separated voltammetric peaks were obtained among guanine, adenine, thymine and cytosine, which lead to the feasibility for the simultaneous determination of all of them in a mixture without separation or pretreatment. Linear calibration curves were obtained from 0.125 to 200.0 μM for adenine, 0.125 to 175.0 μM for guanine, 2.50 to 650.0 μM for thymine, and 2.50 to 650.0 μM for cytosine. This sensor also exhibits good stability, reproducibility and long lifetime.
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