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  • Title: Blueberry extracts protect testis from hypobaric hypoxia induced oxidative stress in rats.
    Author: Zepeda A, Aguayo LG, Fuentealba J, Figueroa C, Acevedo A, Salgado P, Calaf GM, Farías J.
    Journal: Oxid Med Cell Longev; 2012; 2012():975870. PubMed ID: 23213351.
    Abstract:
    Exposure to hypobaric hypoxia causes oxidative damage to male rat reproductive function. The aim of this study was to evaluate the protective effect of a blueberry extract (BB-4) in testis of rats exposed to hypobaric hypoxia. Morphometric analysis, cellular DNA fragmentation, glutathione reductase (GR), and superoxide dismutase (SOD) activities were evaluated. Our results showed that supplementation of BB-4 reduced lipid peroxidation, decreased apoptosis, and increased GR and SOD activities in rat testis under hypobaric hypoxia conditions (P < 0.05). Therefore, this study demonstrates that blueberry extract significantly reduced the harmful effects of oxidative stress caused by hypobaric hypoxia in rat testis by affecting glutathione reductase and superoxide dismutase activities.
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