These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Effects of total saponin from Panax japonicus on acute myocardial ischemia injury induced by ligating coronary artery left anterior descending branch in rats].
    Author: He HB, Xu J, Xu YQ, Wang HW, Di GJ, Li SC, Sun ZW, He YM, Yuan D.
    Journal: Zhong Yao Cai; 2012 May; 35(5):744-9. PubMed ID: 23213738.
    Abstract:
    OBJECTIVE: To investigate the cardioprotective effects of total saponin from Panax japonicus pretreating on acute myocardial ischemia injury induced by ligating coronary artery left anterior descending branch (LAD) in rats. METHODS: Rats were divided into sham group, model group and total saponin group. The treatment group was given total saponin of Panax japonicus. After pretreating for 7 days, the rats' acute myocardial ischemia model was induced by LAD. The electrocardiogram, hemodynamics, infarct size and histomorphology were assessed 12 h after LAD, the serum levels of phosphokinase (CK), lactate dehydrogenase (LDH), superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) were also measured. RESULTS: Compared with the model group, total saponin from Panax japonicus significantly improved heart function, heart histomorphology, opposed ECG T wave decreased and decreased infarct size; Remarkably decreased the contents of LDH, CK and MDA, increased the activity of SOD, CAT. CONCLUSION: Total saponin from Panax japonicus has cardioprotective effects on acute myocardial ischemic injury and the mechanism may be related to antioxidation.
    [Abstract] [Full Text] [Related] [New Search]