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  • Title: [Application of TRUST, TP-ELISA and TPPA in the serologic diagnosis of syphilis].
    Author: Wang TT, Li Q, Yu JF, Xiao CY, Zhang LP.
    Journal: Zhonghua Nan Ke Xue; 2012 Nov; 18(11):1020-2. PubMed ID: 23214254.
    Abstract:
    OBJECTIVE: To investigate the application value of toluidine red unheated serum test (TRUST), treponema pallidum enzyme-linked immunosorbent assay (TP-ELISA) and treponema pallidum particle agglutination assay (TPPA) in the serologic diagnosis of syphilis. METHODS: We collected serum samples from 12 622 inpatients, 2 253 outpatients and 1 500 subjects in the medical examination center, and screened them by TRUST and TP-ELISA, followed by quantitative tests using TRUST and TPPA. RESULTS: Among the 16 375 cases, clinically diagnosed syphilis was confirmed in 384, with a positive rate of 100% either by TRUST (1:2 -1 :16) or TPPA (1:80 - 1:2 560), and 92.2% by TP-ELISA. CONCLUSION: TP-ELISA and TRUST should be simultaneously used for syphilis screening, but not TP-ELISA alone, and the results should be confirmed by TPPA. The combination of the three methods plays a valuable role in reducing the misdiagnosis and missed diagnosis, and contributes to the early and accurate diagnosis of syphilis.
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