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  • Title: Cytotoxic cyclic depsipeptides from the Australian marine sponge Neamphius huxleyi.
    Author: Tran TD, Pham NB, Fechner G, Zencak D, Vu HT, Hooper JN, Quinn RJ.
    Journal: J Nat Prod; 2012 Dec 28; 75(12):2200-8. PubMed ID: 23215348.
    Abstract:
    Three new cyclic depsipeptides, neamphamides B (2), C (3), and D (4), were isolated from the Australian sponge Neamphius huxleyi. The planar structural characterization of these molecules was elucidated using 2D NMR experiments and ESI-FTICR-MS(n). Their configurations were determined by Marfey's method and J-based NMR analysis. These new metabolites inhibited the growth of human cell lines (A549, HeLa, LNCaP, PC3, and NFF) with IC(50) values ranging from 88 to 370 nM. However, neamphamide D causes A549 cell proliferation at subcytotoxic doses and should be treated cautiously as a cytotoxic compound.
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