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  • Title: Weber-Christian disease associated with the tip variant of focal segmental glomerulosclerosis: a case report.
    Author: Sterling KA, Karam S, Taylor N, Cathro HP.
    Journal: Ultrastruct Pathol; 2012 Dec; 36(6):415-8. PubMed ID: 23216240.
    Abstract:
    Weber-Christian disease (W-CD) is associated with relapsing nodular panniculitis and a variety of systemic findings. Renal parenchymal involvement has been rarely reported. The authors describe a case of nephrotic syndrome in an African-American man with a W-CD flare. The patient had chills and low-grade fever with painful lower extremity skin lesions. A renal biopsy demonstrated the tip variant of focal segmental glomerulosclerosis (FSGS). The kidney biopsy also suggested parenchymal involvement by W-CD disease, with supportive ultrastructural findings. The synchronous W-CD flare and biopsy-proven FSGS and the rapid and sustained response of both to limited treatment suggest a causative association.
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