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  • Title: Synthesis of fluorinated cyclopropyl amino acid analogues: toward the synthesis of original fluorinated peptidomimetics.
    Author: Milanole G, Couve-Bonnaire S, Bonfanti JF, Jubault P, Pannecoucke X.
    Journal: J Org Chem; 2013 Jan 18; 78(2):212-23. PubMed ID: 23227990.
    Abstract:
    A straightforward, easy, and practical access to various amino acid analogues (methionine, leucine, lysine, and arginine) from a unique fluorinated cyclopropane scaffold is described. Moreover, the synthesis, for the first time, of one tripeptide incorporating a fluorinated cyclopropane amino acid (FCAA) analogue is reported.
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