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  • Title: Kadcoccitones A and B, two new 6/6/5/5-fused tetracyclic triterpenoids from Kadsura coccinea.
    Author: Liang CQ, Shi YM, Luo RH, Li XY, Gao ZH, Li XN, Yang LM, Shang SZ, Li Y, Zheng YT, Zhang HB, Xiao WL, Sun HD.
    Journal: Org Lett; 2012 Dec 21; 14(24):6362-5. PubMed ID: 23230829.
    Abstract:
    A pair of new triterpenoid epimers, kadcoccitones A (1) and B (2), together with a new biogenetically related compound kadcoccitone C (3), were isolated from Kadsura coccinea. The epimers featured an unprecedented carbon skeleton with a 6/6/5/5-fused tetracyclic ring system unit and a C(9) side chain. Their structures were determined by spectroscopic data, ECD calculation, and single-crystal X-ray diffraction. Compounds 1 and 3 showed anti-HIV-1 activity with an EC(50) value of 47.91 and 32.66 μg/mL, respectively.
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