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Title: Acquired enzymopathy of erythrocyte glucose-6-phosphate dehydrogenase in acute viral hepatitis. Author: Kwiatkowska J, Kwiatkowska D, Andrzejak R, Zatoński W. Journal: Clin Chim Acta; 1978 Feb 01; 83(1-2):75-9. PubMed ID: 23232. Abstract: Erythrocyte glucose-6-phosphate dehydrogenase from patients with acute viral hepatitis has been purified and characterized. The enzyme showed decreased activity (relative to protein), reduced affinity for glucose 6-phosphate and was inactivated at 45 degrees C or at low pH values. The activity and properties of normal erythrocyte enzyme, incubated in vitro with blood plasma of patients, showed a similar pattern of modifications. Incubation with bilirubin affected the enzyme stability, but not its activity or affinity for substrate.[Abstract] [Full Text] [Related] [New Search]