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  • Title: Antiphospholipid syndrome presenting as pulmonary thrombosis and pancreatitis in a young man.
    Author: Phatak S, Redkar N, Patil MA, Karnik ND.
    Journal: BMJ Case Rep; 2012 Dec 12; 2012():. PubMed ID: 23235100.
    Abstract:
    The antiphospholipid syndrome and protein-S deficiency are known prothrombotic conditions. The confirmation of the latter in a patient with a recent antiphospholipid syndrome-associated thrombosis may be difficult as protein-S levels are low in a patient in the wake of recent thrombosis, antiphospholipid antibodies themselves may be targeted against protein-S and oral anticoagulation with warfarin may further bring down protein-S levels. We report a case of a 29-year-old man presenting with widespread unprovoked thrombosis in the form of pulmonary thromboembolism, neck vein thrombosis and pancreatitis. He was found to have antiphospholipid syndrome with low protein-S levels on two occasions. He was anticoagulated with heparin and improved over a 24-day hospital stay marred by the development of an exudative pleural effusion.
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