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  • Title: Fibrinogen Barcelona II: a new case of A alpha 16 Arg----His substitution.
    Author: Borrell M, Vila L, Solá J, Coll I, Fontcuberta J.
    Journal: Haemostasis; 1990; 20(1):1-7. PubMed ID: 2323678.
    Abstract:
    We describe a new congenital dysfibrinogenemia: fibrinogen Barcelona II in 8 members of a family with no major bleeding or thrombotic tendency. Incubation of this fibrinogen with thrombin at low concentration releases half of the expected normal fibrinopeptide A (FPA) and with some delay it releases an abnormal FPA. Abnormal FPA was purified and sequenced and showed a change in the normal amino acid sequence: arginine in position 16 has been substituted by a histidine. This is another case of dysfibrinogenemia in which A alpha 16 Arg----His has been identified as the cause of abnormal behavior of the fibrinogen molecule.
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