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  • Title: [Methaemoglobinaemia in a child treated with Emla(®) cream: circumstances and consequences of overdose].
    Author: Schmitt C, Matulic M, Kervégant M, Tichadou L, Boutin A, Glaizal M, de Haro L.
    Journal: Ann Dermatol Venereol; 2012 Dec; 139(12):824-7. PubMed ID: 23237281.
    Abstract:
    BACKGROUND: Emla(®) cream, a mixture of two local anaesthetics (prilocaine 2.5%, lidocaine 2.5%) has a good benefit-risk profile. However, methaemoglobinaemia can occur, especially when the cream is applied in excessive amounts or over long periods. PATIENTS AND METHODS: The authors report a case of seizure and respiratory disturbances (MetHb=20.1%) after excessive application of Emla(®) (30g) for curettage of molluscum contagiosum in a young girl with eczema. The patient's clinical condition improved after withdrawal of the cream and administration of methylene blue, and she returned home on day two. DISCUSSION: This new case of methaemoglobinaemia in a child following application of Emla(®) cream highlights the importance of strict compliance with the instructions for use of this medicinal product.
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