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  • Title: LL-D49194 antibiotics, a novel family of antitumor agents: taxonomy, fermentation and biological properties.
    Author: Maiese WM, Labeda DP, Korshalla J, Kuck N, Fantini AA, Wildey MJ, Thomas J, Greenstein M.
    Journal: J Antibiot (Tokyo); 1990 Mar; 43(3):253-8. PubMed ID: 2324010.
    Abstract:
    A novel family of antitumor antibiotics, designated LL-D49194, was isolated from the fermentation broth of an actinomycete strain identified as Streptomyces vinaceus-drappus. LL-D49194 alpha 1 and beta 2 were active against Gram-positive and inactive against Gram-negative bacteria in vitro. The beta 1 component was not active against either Gram-positive or Gram-negative bacteria. These antibiotics exhibited significant in vivo activities against several murine tumors, albeit with differing potencies.
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