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  • Title: [Recent advances in the treatment of adrenocortical carcinomas].
    Author: Ducry J, Berthold D, Pralong F.
    Journal: Rev Med Suisse; 2012 Nov 14; 8(362):2181-4, 2186. PubMed ID: 23240320.
    Abstract:
    Adrenocortical carcinomas are rare and aggressive malignant tumors, with an incidence of 1 to 2 cases per million inhabitants. Their diagnosis is made in three clinical situations: during the work up of a syndrome of hormonal hypersecretion, during the work up of locoregional symptoms, or incidentally during an unrelated radiological procedure. Surgery is usually indicated except in situations of advanced metastatic disease. Adjuvant chemotherapy with mitotane is associated with a significant increase in disease-free survival when the drug is administered at adequate therapeutic dosage. Novel anti-mitotic therapies have recently been described for treating recurrent adrenocortical carcinoma under mitotane treatment, but their overall efficacy remains unsatisfactory.
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