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  • Title: A family history study of neuropsychiatric disorders in the adult siblings of autistic individuals.
    Author: Piven J, Gayle J, Chase GA, Fink B, Landa R, Wzorek MM, Folstein SE.
    Journal: J Am Acad Child Adolesc Psychiatry; 1990 Mar; 29(2):177-83. PubMed ID: 2324058.
    Abstract:
    The family history method was used to obtain developmental, social, and psychiatric histories on the 67 adult siblings of 37 autistic probands. Two of 67 siblings (3.0%) were autistic, three siblings (4.4%) had severe social dysfunction and isolation, 10 (15%) had cognitive disorders, and 10 (15%) had received treatment for affective disorder. This study is the first to investigate the frequency of disorders in the adult siblings of autistic probands. These results suggest aggregation of a variety of neuropsychiatric disorders in the siblings of autistic individuals.
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