These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthesis of perylene bisimide-centered glycodendrimer and its interactions with concanavalin A.
    Author: Wang KR, Wang YQ, Li J, An HW, Zhang LP, Zhang JC, Li XL.
    Journal: Bioorg Med Chem Lett; 2013 Jan 15; 23(2):480-3. PubMed ID: 23245514.
    Abstract:
    A novel glycodendrimer based on 18 peripheral α-D-mannoses functionalized perylene bisimide derivative PBI-18-Man was synthesized and its selectively binding interactions for Con A were investigated by CD spectra and turbidity assay, which exhibited strong binding affinity for Con A with the binding constant of 1.3×10(8) M(-1) (7.2×10(6) M(-1) for monomeric mannose, valency corrected), 3 orders of magnitude higher affinity than the monovalent mannose ligand. Furthermore, the inhibitory activity for Con A was studied by ELLA experiment, showed 2 times inhibitor activity than the reference compound (α-MMP).
    [Abstract] [Full Text] [Related] [New Search]