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  • Title: Asymmetric trienamine catalysis: new opportunities in amine catalysis.
    Author: Kumar I, Ramaraju P, Mir NA.
    Journal: Org Biomol Chem; 2013 Feb 07; 11(5):709-16. PubMed ID: 23247590.
    Abstract:
    Amine catalysis, through HOMO-activating enamine and LUMO-activating iminium-ion formation, is receiving increasing attention among other organocatalytic strategies, for the activation of unmodified carbonyl compounds. Particularly, the HOMO-raising activation concept has been applied to the greatest number of asymmetric transformations through enamine, dienamine, and SOMO-activation strategies. Recently, trienamine catalysis, an extension of amine catalysis, has emerged as a powerful tool for synthetic chemists with a novel activation strategy for polyenals/polyenones. In this review article, we discuss the initial developments of trienamine catalysis for highly asymmetric Diels-Alder reactions with different dienophiles and emerging opportunities for other types of cycloadditions and cascade reactions.
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