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  • Title: Direct α-functionalization of simple aldehydes via oxidative N-heterocyclic carbene catalysis.
    Author: Mo J, Yang R, Chen X, Tiwari B, Chi YR.
    Journal: Org Lett; 2013 Jan 04; 15(1):50-3. PubMed ID: 23249417.
    Abstract:
    A direct α-functionalization of simple aldehydes under N-Heterocyclic Carbene (NHC) catalysis and direct generation of ester enolate equivalents from nonfunctionalized aldehydes are disclosed. The catalysis involves selective enolate generation from an oxidatively generated NHC-bounded ester intermediate as a key step. The ester enolate intermediates undergo stereoselective reactions with enones and trifluoromethyl ketones.
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