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  • Title: Ultra-bright and -stable red and near-infrared squaraine fluorophores for in vivo two-photon imaging.
    Author: Podgorski K, Terpetschnig E, Klochko OP, Obukhova OM, Haas K.
    Journal: PLoS One; 2012; 7(12):e51980. PubMed ID: 23251670.
    Abstract:
    Fluorescent dyes that are bright, stable, small, and biocompatible are needed for high-sensitivity two-photon imaging, but the combination of these traits has been elusive. We identified a class of squaraine derivatives with large two-photon action cross-sections (up to 10,000 GM) at near-infrared wavelengths critical for in vivo imaging. We demonstrate the biocompatibility and stability of a red-emitting squaraine-rotaxane (SeTau-647) by imaging dye-filled neurons in vivo over 5 days, and utility for sensitive subcellular imaging by synthesizing a specific peptide-conjugate label for the synaptic protein PSD-95.
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