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  • Title: Ironic case of hepatic dysfunction following the global withdrawal of sitaxentan.
    Author: Don GW, Joseph F, Celermajer DS, Corte TJ.
    Journal: Intern Med J; 2012 Dec; 42(12):1351-4. PubMed ID: 23253000.
    Abstract:
    A patient with pulmonary arterial hypertension secondary to systemic sclerosis was successfully treated with sitaxentan prior to its worldwide withdrawal (because of hepatotoxicity concerns), but then ironically experienced acute hepatic dysfunction during substitute bosentan therapy, and was eventually stabilised on a phosphodiesterase-5 inhibitor.
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