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  • Title: The clinical characteristics of two anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibody-positive interstitial lung disease patients with polymyositis/dermatomyositis.
    Author: Kunimasa K, Arita M, Nakazawa T, Tanaka M, Tsubouchi K, Konishi S, Fukuda Y, Saigusa M, Nakagawa H, Ubukata S, Korogi Y, Fujii T, Mimori T, Ishida T.
    Journal: Intern Med; 2012; 51(24):3405-10. PubMed ID: 23257529.
    Abstract:
    We herein report the clinical and laboratory characteristics of two anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibody-positive interstitial lung disease patients with polymyositis/dermatomyositis (PM/DM). We compared these characteristics with previously published findings. Previous reports and our present cases show that anti-OJ autoantibody-positive interstitial lung disease (ILD) patients with PM/DM lack the manifestations of Raynaud's phenomenon and sclerodactyly and show good prognoses and responses to glucocorticoid therapy. These results indicate that the presence of anti-OJ autoantibodies may be useful for predicting the prognosis of ILD and its clinical course in PM/DM patients.
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