These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: -1722T/C polymorphism (rs733618) of CTLA-4 significantly associated with systemic lupus erythematosus (SLE): a comprehensive meta-analysis.
    Author: Liu J, Zhang H.
    Journal: Hum Immunol; 2013 Mar; 74(3):341-7. PubMed ID: 23261408.
    Abstract:
    This study was to determine whether -318C/T (rs5742909), -1722T/C (rs733618) and -1661A/G (rs4553808) of Cytotoxic T-lymphocyte antigen-4 (CTLA-4) are associated with systemic lupus erythematosus (SLE). The meta-analysis for -318C/T (rs5742909) included 1163 cases and 1520 controls, for -1722T/C (rs733618) included 1016 cases and 1078 controls, and for -1661A/G (rs4553808) included 637 cases and 774 controls. For -318C/T (rs5742909), statistically significant differences were not noted between cases and controls {fixed/random: OR: 1.103, 95% CI: (0.907-1.341), p = 0.326}. For -1661A/G (rs4553808), also no significant difference existed {fixed: OR: 1.024, 95% CI: (0.843-1.244), p = 0.812; random: OR: 1.077, 95% CI: (0.780-1.300), p = 0.958}. But -1722T/C (rs733618) was significantly associated with SLE both in allele {fixed: OR: 0.699, 95% CI: (0.602-0.811), p = 0.000; random: OR: 0.748, 95% CI: (0.565-0.990), p = 0.042} and in genotype {CC/(CT+TT)} meta-analysis {OR: 0.422, 95% CI: (0.297-0.598), p = 0.000}. Also, we subdivided the -1722T/C group (rs733618) into Asia and Mixed subgroups, in Asia subgroup, the SNP was significantly associated with SLE {fixed: OR: 0.628, 95% CI: (0.528-0.746), p = 0.000; random: OR: 0.641, 95% CI: (0.470-0.875), p = 0.005}, in the Mixed subgroup, this polymorphism was not associated with SLE {fixed: OR: 0.946, 95% CI: (0.707-1.267), p = 0.711; random: OR: 0.973, 95% CI: (0.606-1.560), p = 0.908}. These results suggest that there is evidence of association between the CLTA-4 and SLE, especially -1722T/C polymorphism (rs733618).
    [Abstract] [Full Text] [Related] [New Search]