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  • Title: Direct imine acylation: synthesis of the proposed structures of 'upenamide.
    Author: Unsworth WP, Gallagher KA, Jean M, Schmidt JP, Diorazio LJ, Taylor RJ.
    Journal: Org Lett; 2013 Jan 18; 15(2):262-5. PubMed ID: 23265326.
    Abstract:
    The synthesis of the two proposed structures of macrocyclic marine natural product 'upenamide is reported. The key step utilizes direct imine acylation (DIA) with a protected β-hydroxy acid to construct the key tricyclic ABC ring system. The macrocyclization was completed in the final step using a Stille cross-coupling reaction.
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