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  • Title: [A case of drug resistant recurrent gastrointestinal stromal tumor treated surgically by resection, partial hepatectomy and diaphragmectomy].
    Author: Ueda N, Morioka E, Kaida D, Tomita Y, Ohnishi T, Ohno Y, Noguchi M, Funaki H, Kinami S, Omote K, Nakano Y, Kosaka T, Nakata S, Minato H, Takamura H.
    Journal: Gan To Kagaku Ryoho; 2012 Nov; 39(12):2438-40. PubMed ID: 23268103.
    Abstract:
    This 69-year-old man underwent a partial jejunectomy for gastrointestinal stromal tumor(GIST) at the age of 60, and subsequently hepatectomy of segment 5, 6, 7 for liver metastasis of GIST a year later. An irregular mass close to the cutting stump of the liver, and a mass that showed enhanced-effect at segment 4 was discovered 28 months after hepatectomy. In order to treat this second recurrence, we administered imatinib and sunitinib sequentially. The tumor subsequently became drug-resistant, so we removed it surgically together with the liver and a portion of right diaphragm, and a tumor in segment 4. The patient shows no recurrent sign 4 months after surgery. This case suggests that surgical resection should be considered for partially drug resistant GIST.
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